عدد الرسائل : 28
العمر : 46
تاريخ التسجيل : 17/09/2008
|موضوع: Magnesium Sulfate in Severe Perinatal Asphyxia الثلاثاء مايو 19, 2009 4:47 am|| |
Magnesium Sulfate in Severe Perinatal Asphyxia: A Randomized, Placebo-Controlled Trial
Mushtaq Ahmad Bhat, MD,
Bashir Ahmad Charoo, MD,
Javeed Iqbal Bhat, MD,
Sheikh Mushtaq Ahmad, MD,
Syed Wajid Ali, MD and
Masood-ul-Hassan Mufti, MD
Department of Pediatrics, Sheri-Kashmir Institute of Medical Sciences, Srinagar, India
OBJECTIVE. The goal was to study whether postnatal magnesiumsulfate infusion could improve neurologic outcomes at dischargefor term neonates with severe perinatal asphyxia.
METHODS. Forty term (37 weeks of gestation) neonates with severeperinatal asphyxia were studied in a prospective, longitudinal,placebo-controlled trial. Patients were assigned randomly toreceive either 3 doses of magnesium sulfate infusion at 250mg/kg per dose (1 mL/kg per dose) 24 hours apart (treatmentgroup) or 3 doses of normal saline infusion (1 mL/kg per dose)24 hours apart (placebo group). Both groups also received supportivecare according to the unit protocol for perinatal asphyxia.
RESULTS. In the treatment group, moderate encephalopathy waspresent in 35% (7 of 20) of the patients and severe encephalopathyin 65% (13 of 20) of patients at admission. In the placebo group,40% (8 of 20) of patients had moderate encephalopathy and 60%(12 of 20) of patients had severe encephalopathy. The mean serummagnesium concentration in the treatment group remained at 1.2mmol/L for 72 hours after the first infusion. At discharge,22% (4 of 18) of infants in the treatment group had neurologicabnormalities, compared with 56% (10 of 18) of infants in theplacebo group. Also, neuroimaging (head computed tomography)performed on day 14 yielded abnormal findings for fewer infantsin the treatment group than in the placebo group (16% vs 44%).Infants in the treatment group were more likely to be receivingoral feedings (sucking) at discharge than were those in theplacebo group (77% vs 37%). Good short-term outcomes at dischargeoccurred for 77% of the patients in the treatment group, comparedwith 37% of the patients in the placebo group.
CONCLUSION. Postnatal magnesium sulfate treatment improves neurologicoutcomes at discharge for term neonates with severe perinatalasphyxia.
عدد الرسائل : 4042
العمل/الترفيه : طبيب أختصاصي طب الأطفال وحديثي الولادة
المزاج : الحمد لله جيد
تاريخ التسجيل : 15/09/2008
|موضوع: رد: Magnesium Sulfate in Severe Perinatal Asphyxia السبت مايو 23, 2009 2:57 am|| |
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