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 New Treatment for Bronchiolitis in Infants

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dr.alatwane
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تاريخ التسجيل : 17/09/2008

مُساهمةموضوع: New Treatment for Bronchiolitis in Infants   الخميس مايو 14, 2009 4:06 pm


New Treatment for Bronchiolitis in Infants


Nebulized 3% saline in conjunction with
bronchodilators shortened hospital stay and lowered clinical severity.

Current therapy for treating bronchiolitis in infants is only supportive; however,
in several earlier studies, researchers have evaluated whether administering
nebulized 3% saline might reduce severity and speed recovery. In a
meta-analysis conducted by the Cochrane Collaboration, investigators analyzed
four randomized, controlled trials (RCTs) that involved 189 inpatients and 65
outpatients (age, <24 months).

In three inpatient RCTs, infants assigned to
3% saline had a significantly shorter mean length of stay (by 1 day) than
infants who received 0.9% normal saline. In two
inpatient RCTs and the single outpatient trial, infants who received 3% saline,
versus those who received 0.9% saline, had a significantly lower mean
postinhalation clinical score during the first 3 days of treatment.

Comment: These results are encouraging, but some caveats should be noted. In
three of the four trials, bronchodilators
(epinephrine and terbutaline) were added to the 3% saline regimens. In the
other trial, physicians could opt to add albuterol and racemic
epinephrine (used in 37% and 23% of children, respectively). Because the
total number of patients was small, no meaningful data about side effects are
available. Nevertheless, 3% saline, when combined with a bronchodilator, does
seem to shorten length of hospital stay in children who are admitted with
diagnoses of bronchiolitis.

— Howard Bauchner, MD

Published in Journal Watch Pediatrics and Adolescent Medicine May
13, 2009

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dr.aljuraisy
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تاريخ التسجيل : 15/09/2008

مُساهمةموضوع: رد: New Treatment for Bronchiolitis in Infants   الخميس مايو 14, 2009 6:48 pm


Thanks Dr.Salim for your nice issue which we facing commonly in our hosp. best regards

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New Treatment for Bronchiolitis in Infants
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